Survival curves for mice exposed to simvastatin from 10 months of age (top), or to resveratrol from 12 months (bottom). Data are pooled across sites. Males are shown in the left panels, and females in the right panels. Each curve shows results for both high and low doses. The p values reflect log-rank tests, stratified by test site. None of the agents had a significant effect on life span, compared with control mice, at any dose tested. The arrows indicate the age at which the drug treatment was initiated.