Figure 7.

Age effects on total activity in male mice, comparing control to rapamycin-treated mice. The y-axis shows change score, calculated as (activity at 18 months) minus (activity at 7 months in the same mouse). A negative score indicates that the mouse was less active at 18 than at 7 months. (For comparison, the number of beam breaks at 7 months of age for males was approximately 45,000 at The Jackson Laboratory [TJL], 75,000 at University of Michigan [UM], and 71,000 at University of Texas [UT].) The bars show mean and SEM for the change scores. Number of mice tested: 35, 43, and 43 controls and 19, 19, 24 rapamycin-treated mice at TJL, UM, UT, respectively. Asterisks indicate a significant difference between control and rapamycin males at p = .004 at UM and p = .04 at UT.