Table 1.

Sources and Doses of Test Agents

			Dose
Test agent	Source	Age at initiation (mo)	mg/kg food	mg/kg mouse weight per day	mg per mouse per day
Rapamycin	LC Labs; Southwest Research Institute	9	14	2.24	0.067
Simvastatin high	Merck	10	120	20	0.60
Simvastatin low	Merck	10	12	2	0.06
Resveratrol	Orchid/Lalilabs	12	300	50	1.5
Resveratrol	Orchid/Lalilabs	12	1200	200	6

Note: Calculation of dose per mouse and dose per kg mouse body weight per day assume that an average mouse weighs 30 g and consumes 5 g of mouse diet per day. The rapamycin was given in encapsulated form as described in (2).