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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Proteins. 2010 Apr;78(5):1331–1337. doi: 10.1002/prot.22666

Figure 2.

Figure 2

Crystal structures of CXCL12. (a) Cartoon representation of the single protein chain of the asymmetric unit in the P3221 space group CXCL12 crystals. Chemokine structural elements are labeled. (b) The protein composition of the asymmetric unit in the P212121 space group CXCL12 crystals. Ten monomers are arranged as an elongated decamer and form five CC-like dimers. (c) The semi-transparent surface representation of the asymmetric unit of the P3221 space group of CXCL12 and a symmetry mate forms a CXC dimer that interact through their α-helices and β-strand-1. (d) Semi-transparent surface of two representative chains in the decamer of CXCL12 which form a CC chemokine-like dimer and interact with their amino termini and 30’s loops. (e) CXC dimer of CXCL12 (upper panel) compared to CC dimer of CXCL12 (lower panel). Both dimers were aligned using only Chain A of each in the alignment algorithm.