Table V.
Comparison of relevant baseline, time, donation, and efficacy data in patients with osteoarthritis and rheumatoid arthritis with respect to different PABD programmes used.
| Parameter | Patients with osteoarthritis | Patients with rheumatoid arthritis | ||||
|---|---|---|---|---|---|---|
| Two single-unit deposit (2SUD) (n=60) | One double-unit deposit (DUD) (n=100) | Two single-unit deposit (2SUD) (n=24) | One double-unit deposit (DUD) (n=50) | |||
| EBV (L) | 4.7±0.8 | ns | 4.6±0.7 | 4.3±0.6 | ns | 4.2±0.7 |
| Initial Hct (%) | 41.4±4 a | ns | 39.9±4 b, e | 40.5±4 c | * | 37.4±4 d, e |
| Initial RBC mass (L) | 1.8±0.4 | ns | 1.7±0.4 | 1.6±0.3 | * | 1.4±0.3 |
| Total blood volume deposited (mL) | 430 each (860) |
* ns |
860 860 |
430 each (860) |
* ns |
860 860 |
| Total d RBC mass (mL) | 347±30 | ns | 343±36 | 336±30 | ns | 322±32 |
| T1-S (days) | 26.9±2.5 | ns | 25.9±2.9 | 27.4±1.2 | ns | 27.0±2.9 |
| T1–T2 (days) | 14.0±1.0 | - | - | 14.0±0.6 | - | - |
| T2-S (days) | 13.0±2.4 | - | - | 13.1±2.4 | - | - |
| Hct at 2nd PABD | 39.3±3.6 | - | - | 37.6±3.5 | - | - |
| Pre-operative Hct (%) | 37.2±4 a | ns | 37.9±4 b, f | 35.8±5 c | ns | 35.3±4 d, f |
| Δ Hct (%)(pre-op Hct – initial Hct) | −4.2±3.2 | * | −2.0±3.0 | −4.7±3.9 | * | −2.2±2.8 |
| Pre-operative RBC mass (L) | 1.6±0.4 | ns | 1.6±0.4 | 1.4±0.3 | ns | 1.3±0.3 |
| +RBC to 1st PABD (mL) | 89±119 | * | 261±114 | 60±77 | * | 238±112 |
| +RBC to 2nd PABD (mL) | 79±119 | - | - | 89±120 | - | - |
| +RBC total (mL) | 168±133 | * | 261±114 | 149±152 | * | 238±112 |
| +RBC (% d RBC) | 48.4 | na | 76.1 | 44.3 | na | 73.9 |
PABD=pre-operative autologous blood donation; EBV=patient’s estimated blood volume (calculated); Hct=haematocrit; Total d RBC-mass=total RBC mass deposited by PABD; T1-S=time-interval between first PABD and surgery; T1–T2=time interval between first and second PABD; T2-S=time interval between second PABD and surgery; +RBC=increase (regeneration) of RBC mass in response to PABD; +RBC(% d RBC)=increase in RBC mass calculated as a percentage of RBC mass deposited. data are given with mean±SD;
P<0.05.; ns=not statistically significant; na=not analysed; calculations were based on systemic Hct (systemic Hct = venous Hct x 0.914). Data drawn from Singbartl et al. (2007)22.