Table II.
Clinical and laboratory data of the 19 multiple myeloma patients receiving ABO-mismatched HPC from related donors following non-myeloablative conditioning.
| Patient | Age (years) | Sexa | RBC group | CD34+ cells/Kg received | DLI | GvHD gradeb | Engraftment | Chimerism | N | Outcomed | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ANCc (day) | Plateletsc (day) | Day 30 | Day 100 | RBC transf. | ||||||||
| Minor ABO mismatch | ||||||||||||
| 1 | 54 | F/F | A/AB | 5.8 | 0 | I S | 11 | 0 | 50 | 95 | 0 | NCR, alive Day 547 |
| 2 | 50 | F/M | 0/A | 5.1 | 0 | 0 | 0 | 0 | 100 | 100 | 0 | CR, alive Day 1300 |
| Major ABO mismatch | ||||||||||||
| 1 | 55 | M/F | 0/A | 5.1 | 0 | I S | 12 | 9 | 97 | 97 | 2 | CR, alive Day 425 |
| Bidirectional incompatibility | ||||||||||||
| 1 | 62 | F/M | B/A | 7.9 | 0 | 0 | 0 | 0 | 94 | 95 | 8 | NCR, died Day 100 |
| 2 | 54 | M/M | B/A | 3 | 0 | I S | 8 | 13 | 93 | 97 | 8 | CR, alive Day 310 |
a
Recipient/donor; F=female, M=male; DLI, donor lymphocyte infusions;
b
GvHD grades 0-IV; S=skin,
c
Absolute neutrophil count >0.5x109/L for 3 consecutive days and unsupported platelet count >20x109/L;
d
NCR=near complete remission, CR=complete remission.