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. Author manuscript; available in PMC: 2011 Jan 14.
Published in final edited form as: Synthesis (Stuttg). 2010 Apr 20;41(16):i. doi: 10.1002/chin.201016160

Table 3.

N8-Substituted Pyrimido[5,4-e]-1,2,4-triazine-5,7(6H,8H)-diones 11 from Regiospecific Alkylation of 10

graphic file with name nihms248500u3.jpg
Entry Substrate X R Product Yield (%)
1 10q Cl Pr 11a 47
2 10s OMe (CH2)2NEt2a 11b 22
3 10n H (CH2)2OH 11c 43
4 10n H (CH2)2Ph 11d 39
5 10p F 4-t-BuC6H4CH2 11e 71
6 10q Cl 2-FC6H4CH2 11f 57
7 10n H 3-FC6H4CH2 11g 66
8 10s OMe 4-FC6H4CH2 11h 81
9 10p F 3,4-F2C6H3CH2 11i 91
10 10s OMe 3,4-F2C6H3CH2 11j 87
a

Chloride reacted instead of bromide.