Fig 58.5.

Sensitivity of model output to parameter variations is handled by a set of operations integrated into the Sigmoid environment. These functions or their user-defined variants can allow fast and efficient generation of a set of solutions corresponding to variation of any parameter number from one to all and storage of these solutions in a database that can be queried to form various metrics of model performance. The results can be used to analyze the robustness of various models of a specific biochemical system of interest