TABLE 4.

Negatively enriched gene sets related to inflammation and cancer in rectosigmoid biopsies before and after diet-induced weight loss in all 10 subjects¹

Name of gene set	Size	ES	NES	P	FDR
CYTOKINE_ACTIVITY	72	−0.51	−2.17	<0.001	<0.001
CHEMOKINE_RECEPTOR_BINDING	34	−0.65	−2.30	<0.001	<0.001
CHEMOKINE_ACTIVITY	33	−0.68	−2.36	0.004	<0.001
INFLAMMATORY_RESPONSE	108	−0.46	−2.02	<0.001	<0.001
TNFALPHA_ALL_UP	70	−0.48	−2.2	<0.001	<0.001
TNFALPHA_30MIN_UP	39	−0.55	−2.00	<0.001	0.008
CROONQUIST_IL6_STROMA_UP	36	−0.61	−2.20	0.002	0.001
IL6_FIBRO_UP	42	−0.50	−1.82	<0.001	0.009
IL1 KC UP	38	−0.63	−2.24	<0.001	<0.001
IL17ANDTNF KC UP	28	−0.63	−2.11	<0.001	<0.001
IL17 GAFFEN	30	−0.56	−1.95	<0.001	<0.001
IL17 KC UP	40	−0.51	−1.85	<0.001	0.002
ADDITIVE IL17 AND TNFA KC	181	−0.35	−1.67	<0.001	0.008
EICOSANOID_SYNTHESIS	15	−0.67	−1.88	0.004	0.027
PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM	23	−0.58	−1.84	0.004	0.037
ICOSANOID_METABOLIC_PROCESS	15	−0.7	−1.99	<0.001	0.042
HSA00590_ARACHIDONIC_ACID_METABOLISM	42	−0.49	−1.80	<0.001	0.046
GLUTATHIONE_METABOLISM	30	−0.65	−2.24	<0.001	0.001
GLUTATHIONE_TRANSFERASE_ACTIVITY	15	−0.71	−2.06	<0.001	0.007
ELECTRON_TRANSPORT_CHAIN	87	−0.66	−2.86	<0.001	<0.001
HSA00190_OXIDATIVE_PHOSPHORYLATION	105	−0.66	−2.82	<0.001	<0.001
PROTEASOME_DEGRADATION	30	−0.66	−1.81	0.002	0.045
UBIQUINONE_BIOSYNTHESIS	14	−0.66	−2.02	<0.001	0.001
PROTEASOME	17	−0.66	−2.04	<0.001	<0.001

¹Size, number of genes analyzed for each gene set; ES, enrichment score; NES, normalized ES; P, P value of ES; FDR, false discovery rate. Gene sets with P ≤ 0.005 and an FDR ≤5% are shown.