TABLE 3.

Incident hypertension for total flavonoid intakes and flavonoid subclasses (quintiles of cumulative intakes: quintile 5 compared with quintile 1) in the Nurses' Health Study (NHS) I, the NHS II, and the Health Professionals Follow-Up Study (HPFS) restricted to participants ≤60 y of age¹

	NHS I	NHS II	HPFS	Pooled	P for age interaction
Flavonols
Age and smoking adjusted	0.88 (0.81, 0.95)	1.01 (0.95, 1.07)	0.94 (0.83, 1.08)	0.96 (0.90, 1.02)	0.26
Multivariate adjusted	0.91 (0.84, 0.99)	1.00 (0.94, 1.07)	0.96 (0.82, 1.11)	—	—
Flavones
Age and smoking adjusted	0.94 (0.87, 1.02)	0.81 (0.76, 0.86)	0.87 (0.76, 0.99)	—	—
Multivariate adjusted	1.06 (0.97, 1.16)	0.95 (0.88, 1.01)	1.03 (0.88, 1.21)	1.00 (0.93, 1.09)	0.97
Flavonones
Age and smoking adjusted	0.93 (0.86, 1.01)	0.86 (0.81, 0.92)	0.84 (0.73, 0.94)	1.00 (0.95, 1.05)	0.56
Multivariate adjusted	1.04 (0.95, 1.14)	0.98 (0.92, 1.05)	1.02 (0.87, 1.19)	—	—
Flavan-3-ols
Age and smoking adjusted	0.92 (0.86, 1.00)	1.03 (0.97, 1.09)	1.00 (0.88, 1.14)	—	—
Multivariate adjusted	0.94 (0.81, 1.02)	1.03 (0.97, 1.09)	1.05 (0.92, 1.21)	1.00 (0.94, 1.07)	0.44
Anthocyanins
Age and smoking adjusted	0.79 (0.73, 0.85)	0.76 (0.72, 0.81)	0.79 (0.69, 0.90)	—	—
Multivariate adjusted	0.89 (0.81, 0.97)***	0.87 (0.81, 0.92)***	0.93 (0.80, 1.09)	0.88 (0.84, 0.93)***	0.02*
Polymers
Age and smoking adjusted	0.92 (0.85, 0.99)	1.02 (0.96, 1.08)	0.96 (0.84, 1.09)	—	—
Multivariate adjusted	0.95 (0.88, 1.03)	1.00 (0.94, 1.06)	1.05 (0.91, 1.20)	0.99 (0.95, 1.03)	0.48
Total flavonoids
Age and smoking adjusted	0.90 (0.83, 0.97)	1.00 (0.96, 1.08)	0.94 (0.83, 1.07)	—	—
Multivariate adjusted	0.95 (0.88, 1.03)	1.01 (0.95, 1.07)	1.06 (0.92, 1.22)	1.00 (0.95, 1.05)	—

¹All values are relative risks; 95% CIs in parentheses. ***P < 0.001, *P < 0.05.