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Metabolic fate of the orally consumed deuterium-labeled choline. The d9-choline tracer contained deuterium-labeled methyl groups facilitating the examination of the metabolic fate of choline-derived methyl groups in addition to the intact molecule. THF, tetrahydrofolate; MTHFR, 5,10-methylenetetrahydrofolate reductase; PEMT, phosphatidylethanolamine N-methyltransferase; GNMT, glycine N-methyltransferase; CK, choline kinase; CHDH, choline dehydrogenase.
