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. 2010 Dec 22;93(2):356–367. doi: 10.3945/ajcn.110.008359

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FIGURE 2. — Mean (±SD) fasting blood concentrations of daidzein in participants at baseline and after 1 and 2 y of treatment. Blood concentrations of daidzein were compared between the 3 treatment groups over time by generalized estimating equation (GEE) techniques to assess the effect of group, time, and group × time interaction with repeated measures accounted for. A significant group × time interaction (P < 0.001) was detected; therefore, groups were compared at each time point by using contrasts and multiple comparison procedures provided by GEE analysis. The data were log transformed before analysis because of a highly skewed distribution. The blood concentrations of daidzein after 1 and 2 y of isoflavone treatment (80 or 120 mg/d) were significantly (P < 0.001) greater than their respective baseline values. The blood concentrations of daidzein in subjects receiving the 120-mg/d treatment were also significantly greater (P < 0.001) than the respective values in subjects who received the 80-mg/d treatment.