TABLE 1.
Characteristics of BE and esophageal cancer cases and controls
| SDH |
ACS |
|||||||
| Controls | BE without dysplasia | BE with dysplasia | P-value1 | Controls | EAC | ESCC | P-value1 | |
| n (%) | n (%) | |||||||
| n | 577 | 266 | 101 | 1507 | 636 | 245 | ||
| Age, y | 0.08 | <0.0001 | ||||||
| <50 | 110 (19.0) | 54 (20.3) | 14 (13.9) | 268 (17.8) | 55 (8.6) | 17 (6.8) | ||
| 50–59 | 200 (34.6) | 84 (31.6) | 24 (23.8) | 393 (26.1) | 178 (28.0) | 59 (24.3) | ||
| 60–69 | 179 (31.0) | 84 (31.6) | 37 (36.6) | 507 (33.6) | 220 (34.6) | 85 (34.7) | ||
| ≥70 | 89 (15.4) | 44 (16.5) | 26 (25.7) | 339 (22.5) | 183 (28.8) | 84 (34.3) | ||
| Gender | 0.02 | <0.0001 | ||||||
| Male | 369 (64.0) | 168 (63.2) | 79 (78.2) | 996 (66.1) | 560 (88.1) | 147 (60.0) | ||
| Female | 208 (36.0) | 98 (36.8) | 22 (21.8) | 511 (33.9) | 79 (12.0) | 98 (40.0) | ||
| Educational status | <0.001 | <0.0001 | ||||||
| High school only | 226 (39.3) | 130 (48.9) | 35 (34.7) | 616 (40.9) | 266 (41.8) | 140 (57.1) | ||
| Technical/diploma | 224 (38.8) | 101 (38.0) | 54 (53.5) | 657 (43.6) | 315 (49.0) | 84 (34.3) | ||
| University | 127 (22.0) | 35 (13.2) | 12 (11.9) | 234 (15.5) | 55 (8.7) | 21 (8.6) | ||
| BMI, kg/m2 | 0.02 | <0.0001 | ||||||
| <25.0, | 211 (37.0) | 76 (29.1) | 27 (27.0) | 541 (36.2) | 150 (24.1) | 130 (55.6) | ||
| 25–29.9 | 235 (41.2) | 105 (40.2) | 47 (47.0) | 642 (42.9) | 253 (40.7) | 70 (29.9) | ||
| ≥30.0 | 124 (21.9) | 80 (30.7) | 26 (26.0) | 312 (20.9) | 219 (35.2) | 34 (14.5) | ||
| Heartburn or acid reflux symptoms in previous 10 y | <0.001 | <0.0001 | ||||||
| Never | 282 (49.0) | 40 (15.2) | 10 (10.0) | 649(43.1) | 162 (25.6) | 111 (45.9) | ||
| <1/mo | 156 (27.0) | 36 (13.6) | 17 (17.0) | 460 (30.5) | 94 (14.8) | 31 (12.8) | ||
| ≥1/mo but <1/wk | 80 (13.8) | 74 (28.0) | 25 (25.0) | 218 (14.5) | 143 (22.6) | 32 (13.2) | ||
| Daily | 59 (10.2) | 114 (43.2) | 48 (48.0) | 180 (11.9) | 235 (37.1) | 68 (28.1) | ||
| Pack-years of smoking | <0.001 | <0.0001 | ||||||
| Never smoked | 307 (53.1) | 90 (33.8) | 23 (22.8) | 673 (44.7) | 157 (24.7) | 56 (23.1) | ||
| >0–14.9 | 113 (19.6) | 63 (23.7) | 24 (23.8) | 380 (25.2) | 127 (20.0) | 48 (19.8) | ||
| 15–29.9 | 67 (11.6) | 54 (20.3) | 27 (26.7) | 199 (13.2) | 123 (20.8) | 49 (20.2) | ||
| ≥30.0 | 90 (15.7) | 59 (22.2) | 27 (26.7) | 255 (16.9) | 220 (34.6) | 90 (37.0) | ||
| Alcohol intake,2 standard drinks/wk | 0.17 | <0.0001 | ||||||
| None | 65 (11.3) | 36 (13.6) | 4 (4.0) | 161 (10.7) | 50 (7.9) | 31 (12.7) | ||
| <1–6 | 221 (38.4) | 104 (39.3) | 40 (40.0) | 573 (38.0) | 182 (28.7) | 65 (26.6) | ||
| 7–20 | 180 (31.3) | 69 (26.0) | 32 (32.0) | 482 (32.0) | 222 (35.0) | 51 (20.9) | ||
| ≥21 | 110 (19.1) | 56 (21.1) | 24 (24.0) | 291 (19.3) | 181 (28.5) | 97 (39.8) | ||
| NSAID use in previous 5 y | 0.16 | 0.23 | ||||||
| Never | 270 (46.8) | 129 (48.5) | 49 (48.5) | 657 (43.7) | 2968 (47.0) | 124 (51.5) | ||
| Occasionally | 177 (30.7) | 70 (26.3) | 28 (27.7) | 472 (31.4) | 173 (27.5) | 66 (27.4) | ||
| Less than weekly | 62 (10.8) | 20 (7.5) | 7 (6.9) | 145 (9.7) | 57 (9.1) | 19 (7.9) | ||
| At least weekly | 68 (11.8) | 47 (17.7) | 17 (16.8) | 228 (15.2) | 114 (16.5) | 32 (13.3) | ||
1
-value from chi-square test used to compare frequencies or proportions in 2 or more groups.
2
One standard drink contains 10 g of ethanol.