Fig 6.

Hemodynamic performance as a function of infarct size for stroke volume compensated and noncompensated simulations with infarct compliance = 7 mL/mm Hg. Left ventricular (LV) end-diastolic volume (EDV) and end-diastolic pressure (EDP) increase with infarct size for both compensated and noncompensated models. Ejection fraction (EF) decreases with infarct size. Compensation (Comp) has no effect on EF due to an increase in EDV and a constant LV stroke volume (LVSV). The SV compensation maintains peak LV pressure; however, in the non-compensated (Non-Comp) model, pressure decreases as infarct size increases. In the noncompensated model, LV oxygen consumption (LVO₂) decreases slightly with infarct size. After compensation, LVO₂ increases with increasing infarct size. This result is due primarily to the maintenance of normal LV pressure in the compensated model.