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. Author manuscript; available in PMC: 2011 Jan 14.
Published in final edited form as: Nat Rev Drug Discov. 2009 Oct;8(10):794–805. doi: 10.1038/nrd2875

Figure 1. Therapeutic Targets of the Arachidonate Cascade.

Figure 1

Three major pathways the cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) pathways can metabolize arachidonic acid. Inhibitors of the COX-1 and COX-2 enzymes are used for the treatment of pain, inflammation and blood clotting and prostacyclin analogs are used to treat pulmonary hypertension. Leukotriene receptor antagonists that inhibit the cysteinyl leukotriene CysLT1 receptor are used to treat asthma and allergies. Soluble epoxide hydrolase inhibitors that increase epoxyeicosatrienoic acid levels are being developed for the treatment of cardiovascular diseases and inflammation.