Table 1.
Molecular parameters derived from simultaneous fitting of variable temperature NMRD of albumin-bound gadolinium complexes. See text for details. Numbers in parentheses represent one standard deviation. RSD = relative standard deviation.
| |
τR (ns) |
τm310 (ns) |
τv (ps) |
ΔH‡ (kJ/mol) |
Δ2 (1018 s-2) |
F2 |
|---|---|---|---|---|---|---|
| Gd1a | 4.3 (0.2) | 108 (14) | 18 (2) | 42.2 (2.5) | 2.80 (0.14) | 0.49 (0.02) |
| Gd1b | 3.7 (0.2) | 34.1 (6.7) | 22 (3) | 42.3 (4.2) | 3.39 (0.12) | 0.46 (0.01) |
| Gd1c | 4.3 (0.2) | 16.4 (1.8) | 19 (2) | 43.7 (2.8) | 3.23 (0.09) | 0.56 (0.01) |
| Gd1d | 5.1 (0.2) | 49.2 (2.5) | 19 (1) | 56.2 (1.2) | 3.85 (0.07) | 0.59 (0.01) |
| Gd1e | 4.2 (0.2) | 19.8 (2.6) | 20 (2) | 31.6 (3.3) | 3.45 (0.08) | 0.54 (0.01) |
| Gd1f | 5.7 (0.2) | 75.3 (.57) | 18 (1) | 41.3 (1.6) | 3.97 (0.11) | 0.68 (0.01) |
| Gd1g | 4.7 (0.2) | 9.8 (0.7) | 18 (1) | 43.3 (2.4) | 3.56 (0.09) | 0.54 (0.01) |
| Gd1h | 4.3 (0.2) | 37.6 (4.3) | 21 (2) | 47.9 (2.5) | 3.93 (0.10) | 0.52 (0.01) |
| Gd1i | 3.8 (0.2) | 24.0 (3.7) | 21 (3) | 47.9 (3.5) | 3.36 (0.11) | 0.46 (0.01) |
| Gd1j | 3.9 (0.2) | 64.7 (8.9) | 21 (2) | 40.1 (2.8) | 3.33 (0.11) | 0.48 (0.01) |
| Gd2b | 7.6 (1.9) | 441 (67) | 17 (3) | 31.3 (3.0) | 4.47 (0.73) | 0.62 (0.14) |
| Gd2c | 11.6 (6.5) | 579 (99) | 18 (5) | 30.9 (3.4) | 5.97 (1.68) | 0.8 (0.34) |
| Gd2d | 11.4 (5.9) | 570 (92) | 17 (4) | 30.6 (3.2) | 5.71 (1.46) | 0.8 (0.32) |
| Gd2f | 13.8 (7.3) | 536 (91) | 18 (4) | 23.9 (2.9) | 6.22 (1.57) | 0.8 (0.32) |
| Gd3a | 7.7 (3.0) | 499 (108) | 21 (3) | 10.8 (2.9) | 7.9 (2.2) | 0.8 (0.31) |
| Gd3c | 7.2 (1.9) | 612 (86) | 28 (7) | 13.4 (2.1) | 10.4 (2.5) | 0.72 (0.20) |
| Gd3f | 5.0 (0.6) | 574 (74) | 28 (3) | 33.3 (4.6) | 7.1 (1.0) | 0.53 (0.09) |
| Gd4a | 20 (9.8) | 0.7 (0.1) | 26 (3) | 34.9 (2.4) | 5.56 (0.24) | 0.48 (0.01) |
| Gd4b | 17.2 (6.2) | 1.9 (0.1) | 23 (2) | 30.5 (2.7) | 4.20 (0.10) | 0.62 (0.01) |
| Gd4c | 11.0 (1.9) | 2.4 (0.1) | 25 (2) | 33.8 (2.9) | 4.32 (0.11) | 0.61 (0.01) |
| Gd7a | 6.2 (1.4) | 281 (71) | 17 (3) | 23.2 (4.1) | 4.82 (0.72) | 0.60 (0.12) |
| Gd8a | 8.0 (2.1) | 370 (60) | 16 (3) | 32.1 (3.2) | 4.84 (0.75) | 0.66 (0.14) |
| Gd9a | 7.0 (2.7) | 1.4 (0.1) | 30 (6) | 27.4 (4.1) | 4.94 (0.36) | 0.53 (0.01) |
| Gd10a | 5.6 (1.0) | 2.1 (0.1) | 24 (3) | 31.2 (4.1) | 4.00 (0.15) | 0.69 (0.01) |
| Gd11a | 4.2 (0.2) | 54 (12) | 19 (2) | 24.5 (3.9) | 3.20 (0.13) | 0.69 (0.02) |
| Mean | 7.5 | 199 | 21 | 33.9 | 4.74 | 0.61 |
| Std dev | 4.4 | 238 | 4 | 10.5 | 1.75 | 0.11 |
| RSD | 58% | 120% | 19% | 31% | 37% | 18% |