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. Author manuscript; available in PMC: 2011 Jan 14.
Published in final edited form as: Oncogene. 2007 Apr 30;26(45):6469–6487. doi: 10.1038/sj.onc.1210477

Figure 3.

Figure 3

Schematic of the signaling abnormalities resulting from HER2 overexpression that are felt to contribute to tumorigenesis. HER2 overexpression results in increased HER2 containing dimers of all kinds. Increased HER2-EGFR dimers drive proliferative and invasive functions. Increased HER2 homodimers disrupt cell polarity. Increased HER2-HER3 dimers drive proliferative, survival, invasive, and metabolic functions. Increased HER2 expression results in an increase in the rare ΔHER2 isoform with more potent signaling characteristics.Several transcription factors are induced in HER2 overexpressingcells resulting in a plethora of gene expression changes.