Figure 2.

Class distributions and definitions. Shown are population histograms of the intermediate phenotypes selected for modeling. (A) Frequency for total BAL eosinophil count (in millions) in the study population. The population cut‐off for “high eosinophils” is indicated. (B) Frequency of neutrophil count (in millions). (C) Bronchodilators in response to b‐agonist. Plotted on the x‐axis is percent change FEV₁ in response to albuterol inhalation. (D) Methacholine hyper‐responders. X‐axis is PC₂₀ methacholine. The cut‐offs used to define eosinophil rich, neutrophil rich, bronchodilator response, and methacholine hyper‐sensitive classes are shown.