Table 5. Protection against B. abortus in C57BL/6 wt or TLR4−/− mice immunized with U-Omp19 without adjuvants.
| Strain (n = 5): | wt | TLR4−/− | |||
| Vaccine | Adjuvant | Log10 a CFU of B. abortus 2308 at spleen (mean ± SD) | Units of protection | Log10 a CFU of B. abortus 2308 at spleen (mean ± SD) | Units of protection |
| U-Omp19 | None | 4.60±0.34 b | 1.12 | 4.23±0.20 c | 1.03 |
| PBS | None | 5.72±0.06 | 0 | 5.26±0.54 | 0 |
a
The content of bacteria in spleens is represented as the mean log10 CFU ± SD per group.
b
Significantly different from wt PBS-immunized mice P<0.01 estimated by Student’s test.
c
Significantly different from TLR4−/− PBS-immunized mice P<0.01 estimated by Student’s test.