Table 6. Protective responses against oral Brucella infection elicited by U-Omp19 oral vaccination are mediated by CD4+ T cells and IL-17.
| Vaccine (n = 5) | Treatment | Log10 a CFU of B. abortus 2308 at spleen (mean ± SD) | Units of protection |
| U-Omp19 | Isotype Control | 4.36±0.21 b | 1.14 |
| U-Omp19 | Anti - CD4 | 5.18±0.41 c | 0.32 |
| U-Omp19 | Anti - IL-17 | 5.03±0.58 d | 0.47 |
| PBS | Isotype Control | 5.50±0.09 c | 0 |
| PBS | Anti - IL-17 | 5.66±0.30 c | −0.16 |
a
The content of bacteria in spleens is represented as the mean log10 CFU ± SD per group.
b
Significantly different from PBS-immunized mice P<0.01 estimated by Dunnett's test.
c
Significantly different from U-Omp19 immunized (Isotype Control-treated) mice P<0.01 estimated by Dunnett's test.
d
Significantly different from U-Omp19 immunized (Isotype Control-treated) mice P<0.05 estimated by Dunnett's test.