Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Jan 14;6(1):e16210. doi: 10.1371/journal.pone.0016210

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Thallhammer et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A) Enzyme-dependent stimulation of uncoupled turnover that was dependent on the cofactors ascorbate, and Fe(II) and inhibited by 1 mM of the generic 2OG oxygenase inhibitor pyridine-2,4-dicarboxylate (2,4-PDCA). (B) Enzyme-dependent stimulation of uncoupled 2OG turnover that was sensitive to the oxygen concentration. Turnover was significantly reduced under moderate hypoxia (5.0% oxygen) and negated under more severe hypoxia (1.0%) (C) Testing of potential oligonucleotide substrates; 1-methylguanine (1meG) 3-methylthymine (3meT) and (D) 1-methyladenine (1meA), 3-methylcytosine (3meC), 5-methylcytosine (5meC). No significant increase in ALKBH5 activity was observed in the presence of methylated oligonucleotides.