Effect of salvinorin A (Sal A) on cocaine induced hyperactivity. Drug naive rats were initially injected with vehicle (Veh, 75% DMSO) or Sal A (0.3 mg/kg) followed by saline (1 ml/kg) or cocaine (Coc, 20 mg/kg) and total activity was monitored for 60 min. Data expressed as mean total activity (+SEM). *p<0.05, data compared with Veh/Saline treated group, #p<0.05, data compared with Sal A/Saline treated group. One way ANOVA followed by Tukey test. n= 6–7 for each group.