Table 2. Frequencies of genotypes and alleles of the eNOS gene.
| Polymorphisms | Control (n=120) | POAG (n=102) | p# (χ2) | OR (95% CI) | PCAG (n=88) | p (χ2) | OR (95% CI) | |
|---|---|---|---|---|---|---|---|---|
|
rs743507 | ||||||||
|
Genotypes | ||||||||
| AA |
81 (0.675) |
70 (0.686) |
0.263 (2.675) |
0.205 (0.023–1.872) p=0.122* |
62 (0.705) |
0.570 (1.223) |
0.361 (0.032–4.405) p=0.390* |
|
| AG |
38 (0.317) |
28 (0.275) |
|
|
24 (0.273) |
|
|
|
| GG |
1 (0.008) |
4 (0.039) |
|
1.053 (0.598–1.856) p=0.858** |
2 (0.023) |
|
1.148 (0.632–2.084) p=0.650** |
|
|
Alleles | ||||||||
| A |
0.833 |
0.822 |
0.785 (0.074) |
0.933 (0.569–1.531) |
0.841 |
0.836 (0.043) |
1.057 (0.624–1.792) |
|
| G |
0.167 |
0.178 |
|
|
0.159 |
|
|
|
|
rs3793342 | ||||||||
|
Genotypes | ||||||||
| CC |
91 (0.758) |
66 (0.647) |
0.045 (6.203) |
7.435 (0.880–62.839) p=0.032* |
60 (0.682) |
0.388 (1.893) |
0.361 (0.032–4.405) p=0.390* |
|
| CT |
28 (0.233) |
30 (0.294) |
|
|
26 (0.295) |
|
|
|
| TT |
1 (0.008) |
6 (0.059) |
|
1.712 (0.956–3.067) p=0.069** |
2 (0.023) |
|
1.494 (0.370–1.261) p=0.222** |
|
|
Alleles | ||||||||
| C |
0.875 |
0.794 |
0.021 (5.310) |
1.814 (1.088–3.030) |
0.830 |
0.192 (0.695) |
0.695 (0.401–1.203) |
|
| T |
0.125 |
0.206 |
|
|
0.170 |
|
|
|
|
rs11771443 | ||||||||
|
Genotypes | ||||||||
| CC |
30 (0.250) |
27 (0.265) |
0.952 (0.085) |
0.982(0.531–1.816) p=0.953* |
23 (0.261) |
0.965 (0.071) |
1.084 (0.565–2.077) p=0.809* |
|
| CT |
61 (0.508) |
50 (0.490) |
|
|
45 (0.511) |
|
|
|
| TT |
29 (0.242) |
25 (0.245) |
|
1.080 (0.591–1.975) p=0.802** |
20 (0.227) |
|
1.062 (0.565–1.993) p=0.853** |
|
|
Alleles | ||||||||
| C |
0.504 |
0.510 |
0.906 (0.014) |
1.023 (0.704–1.486) |
0.517 |
0.795 (0.067) |
1.053 (0.713–1.554) |
|
| T |
0.496 |
0.490 |
|
|
0.483 |
|
|
|
|
rs7830 | ||||||||
|
Genotypes | ||||||||
| AA |
23 (0.192) |
18 (0.176) |
0.922 (0.163) |
0.901(0.507–1.560) p=0.721* |
16 (0.182) |
0.967 (0.068) |
0.930 (0.510–1.695) p=0.813* |
|
| AC |
62 (0.517) |
52 (0.510) |
|
|
45 (0.511) |
|
|
|
| CC |
35 (0.292) |
32 (0.314) |
|
0.904 (0.457–1.788) p=0.771** |
27 (0.307) |
|
0.937 (0.462–1.900) p=0.857** |
|
|
Alleles | ||||||||
| A |
0.450 |
0.431 |
0.694 (0.155) |
0.927 (0.634–1.135) |
0.438 |
0.780 (0.064) |
0.951 (0.643–1.406) |
|
| C |
0.550 |
0.569 |
|
|
0.562 |
|
|
|
|
rs3918188 | ||||||||
|
Genotypes | ||||||||
| AA |
5 (0.042) |
4 (0.039) |
0.965 (0.071) |
1.065 (0.278–4.076) p=0.926* |
4 (0.045) |
0.942 (0.119) |
0.913 (0.238–3.503) p=0.894* |
|
| AC |
45 (0.375) |
40 (0.392) |
|
|
31 (0.352) |
|
|
|
| CC |
70 (0.583) |
58 (0.569) |
|
0.941 (0.552–1.606) p=0.825** |
53 (0.602) |
|
1.082 (0.618–1.894) p=0.784** |
|
|
Alleles | ||||||||
| A |
0.229 |
0.235 |
0.879 (0.023) |
1.035 (0.665–1.610) |
0.222 |
0.855 (0.033) |
0.958 (0.601–1.526) |
|
| C | 0.771 | 0.765 | 0.778 | |||||
*p: indicated the P value in dominate model; **p: indicated the p value in recessive model, #p: indicated the p value in general model.