Table 2. Distribution of Polymorphisms in DNA repair genes XPD (Asp312Asn) and XRCC1 (Arg399Gln) and risk estimates for cataract development.
| |
Patients |
Controls |
|
|
||
|---|---|---|---|---|---|---|
| Genotype | n | % | n | % | O.R (95%CI) | p value |
|
XPD | ||||||
| Asp/Asp |
84 |
40.4 |
62 |
41.1 |
1.66(0.90–3.07) |
0.11 |
| Asp/Asn |
79 |
38.0 |
69 |
45.7 |
1.97(1.06–3.63) |
0.03* |
| Asn/Asn |
45 |
21.6 |
20 |
13.2 |
reference |
|
| G (Asp) |
0.59 |
0.64 |
|
|
||
| A (Asn) |
0.41 |
0.36 |
0.82 (0.60–1.12) |
0.21 |
||
|
Recessive model | ||||||
| Asp/Asp + Asp/Asn |
163 |
78.4 |
131 |
86.8 |
|
|
| Asn/Asn |
45 |
21.6 |
20 |
13.2 |
1.81(1.02–3.20) |
0.04* |
|
XRCC1 | ||||||
| Arg/Arg |
90 |
43.3 |
75 |
49.7 |
1.50(0.81–2.79) |
0.20 |
| Arg/Gln |
82 |
39.4 |
56 |
37.1 |
1.23(0.65–2.33) |
0.53 |
| Gln/Gln |
36 |
17.3 |
20 |
13.2 |
reference |
|
| G (Arg) |
0.63 |
0.68 |
|
|
||
| A (Gln) |
0.37 |
0.32 |
0.80(0.59–1.10) |
0.17 |
||
|
Recessive model | ||||||
| Arg/Arg +Arg/Gln |
172 |
82.7 |
131 |
86.8 |
|
|
| Gln/Gln | 36 | 17.3 | 20 | 13.2 | 1.37(0.76–2.46) | 0.30 |