Table 3. Distribution of genotype and allele frequencies of XPD (Asp312Asn) and XRCC1 (Arg399Gln) polymorphisms in controls and patients with different types of cataract.
|
|
Cataract subtypes |
|||
|---|---|---|---|---|
| Genotype | CC (69) | NC (69) | PSC (70) | Controls (151) |
|
XPD | ||||
| Asp/Asp |
26–37.7 |
29–42.0 |
29–41.4 |
62–41.1 |
| Asp/Asn |
23–33.3 |
32–46.4 |
24–34.3 |
69–45.7 |
| Asn/Asn |
20–29.0* |
8–11.6 |
17–24.3 |
20–13.2 |
| G (Asp) |
0.54 |
0.65 |
0.59 |
0.64 |
| A (Asn) |
0.46 |
0.35 |
0.41 |
0.36 |
|
XRCC1 | ||||
| Arg/Arg |
32–46.4 |
25–36.2 |
33–47.1 |
75–49.7 |
| Arg/Gln |
26–37.7 |
31–44.9 |
25–35.7 |
56–37.1 |
| Gln/Gln |
11–15.9 |
13–18.8 |
12–17.1 |
20–13.2 |
| G (Arg) |
0.65 |
0.59 |
0.65 |
0.64 |
| A (Gln) | 0.35 | 0.41 | 0.35 | 0.36 |
*Asp/Asp Vs Asn/Asn significant; OR=2.39, 95% CI=1.11 – 5.12, p=0.03.