Table 4.
A selection of oxidative stress and anti-oxidant defense myocardial genes up and down regulated in Controls versus SW Mexico City, SWMC untreated versus SWMC chocolate treated mice, and Controls versus NWMC untreated mice.
| Controls versus SWMC | ||
|---|---|---|
| Symbol | Gene name | Fold-up or down regulation |
| IL19 | Interleukin 19 | 77.35 |
| Rag 2 | recombination activating gene 2 | 67.54 |
| Mpo | myeloperoxidase | 63.70 |
| IL22 | Interleukin 22 | 45.76 |
| Nox1 | NADPH oxidase 1 | 45.68 |
| Nox 4 | NADPH oxidase 4 | 4.02 |
| Noxo1 | NADPH oxidase organizer 1 | 6.09 |
| Nos 2 | nitric oxide synthase 2, inducible | 4.16 |
| Recq14 | RecQ protein-like 4 | 31.48 |
| Gpx2 | glutathione peroxidase 2 | 28.82 |
| Epx | eosinophil peroxidase | 25.90 |
| Serpin 1b | serpin type 1b | 22.65 |
| Apo E | Apolipoprotein E | −46.60 |
| Gpx 3 | glutathione peroxidase 3 | −25.07 |
| Prdx3 | peroxiredoxin 3 | −9.95 |
| Tmod1 | tropomodulin 1 | −8.40 |
| Cat | catalase | −6.85 |
| Gpx4 | glutathione peroxidase 4 | −4.80 |
| Untreated SW mice versus SWMC chocolate treated | ||
|---|---|---|
| Symbol | Gene name | Fold-up or down regulation |
| Gpx3 | glutathione peroxidase 3 (plasma) | 10.98 |
| APO E | apolipoprotein E | 9.46 |
| Cat | catalase | 5.53 |
| Xirp1 | Cardiomyopathy-associated protein 1 xin actin-binding repeat containing 1 | 2.52 |
| Ngb | Neuroglobin | −20.46 |
| Rag2 | recombination activating gene 2 | −17.99 |
| Lpo | lactoperoxidase | −13.45 |
| IL-19 | Interleukin 19 | −10.37 |
| Gpx7 | glutathione peroxidase 7 | −9.46 |
| Tpo | thyroid peroxidase | −9.34 |
| Nox1 | NADPH oxidase 1 | −8.90 |
| Nox4 | NADPH oxidase 4 | −3.76 |
| Nudt15 | nudix (nucleoside diphosphate linked moiety X)-type motif 15 | −4.80 |
| Prdx1 | Peroxiredoxin 1 | −3.20 |
| Recql4 | RecQ protein 4 | −4.08 |
| Mpo | myeloperoxidase | −8.66 |
| Gpx6 | glutathione peroxidase 6 | −8.25 |
| Aass | alpha-aminoadipate semialdehyde synthase | −6.11 |
| Ccs | copper chaperone for superoxide dismutase | −4.99 |
| Controls versus NWMC mice | ||
|---|---|---|
| Symbol | Gene name | Fold-up or down regulation |
| Rag2 | recombination activating gene 2 | 71.14 |
| Nox1 | NADPH oxidase 1 | 59.97 |
| Tpo | thyroid peroxidase | 58.51 |
| Mpo | myeloperoxidase | 48.99 |
| IL19 | Interleukin 19 | 46.97 |
| Gpx2 | glutathione peroxidase 2 | 45.55 |
| Epx | eosinophil peroxidase | 28.83 |
| Serpin 1b | serpin type 1b | 24.37 |
| Gpx7 | glutathione peroxidase 7 | 20.92 |
| Il22 | Interleukin 22 | 18.86 |
| Sod2 | superoxide dismutase 2, mitochondrial | −14.26 |
| APO E | apolipoprotein E | −7.72 |
| Tmod1 | tropomodulin 1 | −5.05 |
| Zmynd17 | zinc finger, MYND-type containing 17 | −4.94 |
| Gpx3 | glutathione peroxidase 3 | −3.34 |