Table 1.
Brain area | Expression, nA | EC50, μM | Hill coefficient | IC50, nM |
---|---|---|---|---|
Encephalon | 115 ± 35 | 611 ± 77 | 2.0 ± 0.5 | 56 ± 3 |
Midbrain | 346 ± 28 | 661 ± 28 | 1.9 ± 0.1 | 97 ± 4 |
Brain stem | 389 ± 22 | 506 ± 18 | 2.4 ± 0.2 | 72 ± 4 |
For level of expression, the numbers represent Gly-current amplitudes (mean ± SEM), evoked by 1 mM glycine in oocytes injected with encephalon, midbrain, and brain stem mRNAs (n = 26, 43, and 18, respectively). The EC50 and IC50 values were derived from the Hill equation.