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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Pigment Cell Melanoma Res. 2010 Nov 10;24(1):187–196. doi: 10.1111/j.1755-148X.2010.00788.x

Figure 4.

Figure 4

XANES spectra obtained for melanosomes with combined Gpnmb and Tyrp1 mutation identify the basis for spectral differences between melanosomes of C57BL/6J and DBA/2J mice. (A) Significant spectral changes at 284–285 eV and 285–287 eV. (B) Recapitulation of DBA/2J spectral phenotypes in melanosomes from B6.D2-Tyrp1bGpnmbR150X/Sj mice. (C) Lack of phenotype in F1 mice heterozygous for the Tyrp1b and GpnmbR150X mutations. Normalized spectra, mean ± 1 standard deviation; Student’s two-tailed t-test (A & C compared to C57BL/6J; B compared to B6.D2-Tyrp1bGpnmbR150X/Sj) with significance set at 0.05 (red bar); n = number of fields analyzed per genotype.