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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Cytokine. 2010 Nov 23;53(2):130–140. doi: 10.1016/j.cyto.2010.10.009

Figure 3. Regulation of PI3K and GSK3 mediates different outcomes on Th1- and Th2-type immune response.

Figure 3

PI3K/Akt phospho-inactivation of GSK3 augments Th2 type immune responses by attenuating IL-12 production and increasing IL-10 levels from TLR-stimulated innate immune cells. The enhanced Th1 type immune responses upon PI3K inhibition are the result of elevated IL-12 production from TLR-stimulated innate immune cells due to their inability to inactivate GSK3.