Skip to main content
. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Cytokine. 2010 Nov 23;53(2):130–140. doi: 10.1016/j.cyto.2010.10.009

Figure 5. Regulation of STATs by GSK3.

Figure 5

(A) In IFN-γ, GM-CSF, and IL-6 stimulated cells, GSK3 inhibition suppressed both STAT3 and STAT5 activity, but only minimally affected STAT1 and STAT6 activity. (B) GSK3-β inhibition differentially affects early and late STAT1 activation in IFN-γ-treated cells. Inhibition of GSK3 had no effect on early STAT1 activity (<1hr) but diminished late STAT1 phosphorylation by increasing SHP-2 activity. The ability of GSK3 inhibition to reduce STAT1 activity resulted in reduced levels of iNOS, TNF, and RANTES by IFN-γ-stimulated macrophages.