Figure 5.

(Top) Changes in peak (solid lines) and diastolic (dotted lines) [Ca²⁺]_i in response to changes in the conductances of the persistent Na⁺ current (G_Nab), the SR Ca²⁺ leak flux (V_leak), the Na⁺/K⁺ ATPase current (G_NKA) and the NCX (V_NCX). Dashed lines indicate the experimentally measured peak and diastolic [Ca²⁺]_i in the KO cardiomyocytes. (Bottom) Changes in peak (solid lines) and diastolic (dotted lines) [Ca²⁺]_i in response to changes total buffer concentration (B_max) and affinity (K_d).