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. 2011 Jan 19;100(2):304–312. doi: 10.1016/j.bpj.2010.11.084

Figure 1.

Figure 1

Rolling velocities of platelets on various forms of vWF molecule: (A) wt vWF-A1 (n = 14–256), (B) GOF R687E vWF-A1 (n = 12–353), (C) LOF G561S vWF-A1 (n = 23–98), (D) wt vWF-A1A2A3 (n = 10–36), and (E) wt whole vWF (n = 44–277). Because there is decreased association between platelets and LOF G561S vWF-A1 (C), fewer interactions occur at all shear stresses, and none occur at the highest shear stresses measured for other vWF molecules. Measured freestream velocities of platelets perfused across 1% HSA (Δ) are plotted in B to show that the rolling velocity of platelets rolling on GOF R687E vWF-A1 is less than the freestream values. Data represent the mean ± SE of rolling platelets. Each catch-slip transition is statistically significant with p < 0.05.