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Scheme of the modular design of PEG-based aECMs. Stoichiometrically balanced ([Lys]/[Gln] = 1) 8-arm PEG macromers in a buffer solution are enzymatically cross-linked via their pending glutamine acceptor [Gln] and lysine-donor [Lys] FXIIIa substrate sequences to form a hydrogel. By variation of the linker sequence and the initial precursor concentration, aECMs with different stiffness and MMP sensitivities in presence of constant RGD concentrations can be generated.
