Table 2.
Pharmacokinetic parameters of glimepride on coadministration with atorvastatin and rosuvastatin
| Parameters | Glimepiride (6 mg/kg, p.o.) | Atorvastatin (60 mg/kg, p.o) | Rosuvastatin (60 mg/kg, p.o.) | Glimepiride (6 mg/kg, p.o.) + atorvastatin (60 mg/kg, p.o) | Glimepiride (6 mg/kg, p.o.) + rosuvastatin (60 mg/kg, p.o.) |
|---|---|---|---|---|---|
| tmax (h) | 1.22 ± 0.4 | 2.00 ± 0.0 | 4.00 ± 2.0 | 3.33 ± 0.7* | 2.00 ± 0.0 |
| Cmax (ng/ml) | 1,705.02 ± 262.3 | 5,551.95 ± 549.4 | 2,079.19 ± 1,512.5 | 5,318.27 ± 291.1* | 2,950.20 ± 159.57* |
| T1/2 (h) | 6.53 ± 0.96 | 0.64 ± 0.02 | 1.65 ± 0.23 | 3.59 ± 0.14* | 3.25 ± 0.30* |
| Kel (h-1) | 0.11 ± 0.02 | 1.09 ± 0.04 | 0.43 ± 0.06 | 0.19 ± 0.01* | 0.22 ± 0.02* |
| AUC(0−t) (h ng/ml) | 8,814.83 ± 1,335.4 | 12,130.48 ± 1,689.5 | 4,469.57 ± 2,887.3 | 30,723.20 ± 1,416.4* | 14,200.25 ± 1,915.7 |
| AUC(0.−∞) (h ng/ml) | 9,489.44 ± 1,618.5 | 12,144.64 ± 1,687.9 | 6,706.60 ± 3,038.9 | 30,932.78 ± 1,399.8* | 15,717.01 ± 1,298.4 |
| Vd (ml) | 6,100.51 ± 896.3 | 4,731.69 ± 688.5 | 33,655.08 ± 18,262.2 | 1,011.81 ± 88.9* | 1,829.39 ± 262.3* |
| Cl (ml/h) | 666.03 ± 99.3 | 5,116.93 ± 636.4 | 12,928.17 ± 5,858.2 | 194.80 ± 9.22* | 386.83 ± 30.79 |