Table II.
Baseline Characteristics of SARP Participants who enrolled Below the Age of 40 Years by Racial Background & Phenotype Group
| Both Races N=518 |
Black n=162 (31.3%) |
White n=356 (68.7%) |
||||
|---|---|---|---|---|---|---|
| Mild/Mod n=372 |
Severe n=146 |
Mild/Mod n=114 |
Severe n=48 |
Mild/Mod n=258 |
Severe n=98 |
|
| Age at Diagnosis (yrs) | 8(4, 16) | 5(1,14) | 8(4,18) | 4(1,15.5) | 8(4,15) | 5(1,13) |
| Duration of Asthma (yrs) | 17.3(10.6,23.3) | 22.6(14.4,29.2) | 18.4(10.9,23.7) | 22.5(14,27.6) | 17.1(10.6,22.9) | 22.6(15.9,29.2) |
| *BMI (kg/m2) | 25.9(22.7,32.4) | 30.1(25,36.5) | 28.4(24.6,36.8) | 33.9(30.1,45) | 24.9(22.2,29) | 27.5(23.8,24.5) |
| *Baseline Predrug FEV1 (liters) | 2.99(2.56,3.58) | 2.15(1.54,2.75) | 2.57(2.20,2.94) | 1.91(1.53,2.23) | 3.26(2.74,3.73) | 2.28(1.65,3.00) |
| Baseline Predrug FEV1 % Pred | 89(78,99) | 63(48,81) | 83.5(75,94) | 63(52.5,80) | 91(80,101) | 62.5(48,81) |
| Baseline Predrug FVC % Pred | 97.3(89,105) | 81.8(71,95) | 96(86,104) | 82.7(73,90) | 98(89.2,106) | 81.4(68.3,95) |
| FEV1/FVC | 0.77(0.71,0.83) | 0.68(0.55,0.78) | 0.75(0.68,0.82) | 0.68(0.55,0.79) | 0.78(0.72,0.83) | 0.64(0.55,0.78) |
| Max FEV1 Reversal (%) | 9.2(4.9,17.7) | 15.3(6.7,28.9) | 14.1(6,24.6) | 14.6(6.8,26.8) | 8.1(4.3,14.1) | 16.2(6.5,29.5) |
| Log IgE (IU/ml) | 2.18(1.79,2.55) | 2.18(1.78,2.59) | 2.25(1.84,2.71) | 2.31(1.74,2.68) | 2.12(1.74,2.49) | 2.11(1.79,2.52) |
| Atopy | 295(79.3%) | 98(67.1%) | 97(85.1%) | 33(68.8%) | 198(76.7%) | 65(66.3%) |
| ≥5 Positive Skin Tests | 142(38.2%) | 44(30.1%) | 56(49.1%) | 19(39.6%) | 86(33.3%) | 25(25.5%) |
| Female | 255(68.5%) | 94(64.4%) | 79(69.3%) | 34(70.8%) | 176(68.2%) | 60(61.2%) |
| Currently Employed | 220(59.1%) | 91(62.3%) | 74(64.9%) | 28(58.3%) | 146(56.6%) | 63(64.3%) |
| Diagnosed Diabetes | 7(1.9%) | 7(4.8%) | 6(5.3%) | 2(4.2%) | 1(0.4%) | 5(5.1%) |
| Diagnosed Hypertension | 26(7.0%) | 20(13.7%) | 17(14.9%) | 9(18.8%) | 9(3.5%) | 11(11.2%) |
| Diagnosed GERD | 50(13.4%) | 52(35.6%) | 17(14.9%) | 21(43.8%) | 33(14%) | 31(31.6%) |
*
Mean age: 28.99 ± 6.62
Continuous variables: median (25th, 75th percentiles); Categorical variables: n (%)
FEV1: forced expiratory volume in one second
FVC: forced vital capacity ratio
GERD: gastroesophageal reflux disease.
2ndhand smoke exp: secondhand smoke exposure
*
p < 0.15 Black severe vs White severe.