(a).

	IL-12B rs1363670		IL-12B rs6887695
	OR (95% CI)	P value	OR (95% CI)	P value
Gender
Female	1.54 (0.96–2.46)	0.086	0.79 (0.57–1.10)	.178
Male	0.85 (0.51–1.42)	0.608	0.93 (0.66–1.32)	.725
Age at first diagnosis
0–16 years	1.41 (0.69–2.89)	0.317	0.76 (0.42–1.37)	.394
17–40 years	1.28 (0.90–1.81)	0.175	0.92 (0.71–1.19)	.513
>40 years	0.84 (0.43–1.63)	0.747	0.73 (0.46–1.15)	.184
CD location
Colonic	1.16 (0.71–1.89)	0.523	0.94 (0.66–1.34)	.790
Ileal	1.39 (0.89–2.16)	0.153	0.55 (0.38–0.80)	.002
Ileocolonic	1.11 (0.68–1.80)	0.703	1.26 (0.89–1.79)	.206
CD behaviour
Inflammatory	1.23 (0.84–1.81)	0.313	0.83 (0.62–1.11)	.220
Penetrating	0.46 (0.16–1.30)	0.161	1.06 (0.61–1.83)	.888
Stricturing	1.60 (1.01–2.53)	0.055	0.85 (0.59–1.23)	.408
Colonic/inflammatory	1.16 (0.69–1.96)	0.580	0.82 (0.56–1.21)	.332
Ileal/stricturing	1.86 (1.08–3.20)	0.036	0.58 (0.35–0.96)	.035
Any relatives with IBD	1.43 (0.91–2.25)	0.137	0.96 (0.68–1.36)	.859
Bowel resection	1.22 (0.77–1.92)	0.401	0.91 (0.65–1.28)	.609
Smoker at diagnosis	1.47 (0.79–2.74)	0.282	0.91 (0.60–1.39)	.668
Any EIMs	1.33 (0.73–2.42)	0.327	1.1 (0.70–1.74)	.724