(a) Genes upregulated in LSC but downregulated in ITD-Flt3+KSL cells deleted with Survivin (55 genes).
| Symbol | Name | Fold change |
|---|---|---|
| Acaa2 | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) (Acaa2), [NM_177470] | −3.7 |
| Ankrd12 | Mus musculus 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930020E11 product: unknown EST, full insert sequence. [AK086311] | −5.5 |
| Ankrd28 | Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430019N21 product: unknown EST, full insert sequence. [AK088541] | −2.9 |
| Ap1g2 | adaptor protein complex AP-1, gamma 2 subunit (Ap1g2), [NM_007455] | −5.2 |
| Arhgef18 | rho/rac guanine nucleotide exchange factor (GEF) 18 (Arhgef18), [NM_133962] | −3.6 |
| Arrdc1 | arrestin domain containing 1 (Arrdc1), [NM_178408] | −2.1 |
| Atp11a | ATPase, class VI, type 11A, [AK006628] | −2.6 |
| BGLAP | bone gamma carboxyglutamate protein 1 (Bglap1), [NM_007541] | −10.2 |
| Cars | cysteinyl-tRNA synthetase (Cars), [NM_013742] | −2.3 |
| Ccr1 | chemokine (C-C motif) receptor 1 (Ccr1), [NM_009912] | −3.5 |
| Cd96 | CD96 antigen (Cd96), [NM_032465] | −2.1 |
| Cfp | complement factor properdin (Cfp), [NM_008823] | −4.3 |
| Cyyr1 | cysteine and tyrosine-rich protein 1 (Cyyr1), [NM_144853] | −2.7 |
| Dpagt1 | dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) (Dpagt1), [NM_007875] | −2.8 |
| Dpp9 | dipeptidylpeptidase 9 (Dpp9), [NM_172624] | −2.4 |
| Elovl1 | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 (Elovl1), [NM_019422] | −2.5 |
| Ets2 | E26 avian leukemia oncogene 2, 3′ domain (Ets2), [NM_011809] | −2.5 |
| Fgr | Mus musculus Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog (Fgr), mRNA [NM_010208] | −2.9 |
| Gfi1 | growth factor independent 1 (Gfi1), [NM_010278] | −2.7 |
| Gga2 | golgi associated, gamma adaptin ear containing, ARF binding protein 2 (Gga2), [NM_028758] | −2.5 |
| Git2 | G protein-coupled receptor kinase-interactor 2, [AK017943] | −3.1 |
| Hdac10 | histone deacetylase 10 (Hdac10), [NM_199198] | −4.1 |
| Ipo13 | importin 13 (Ipo13), [NM_146152] | −2.3 |
| Isyna1 | myo-inositol 1-phosphate synthase A1 (Isyna1), [NM_023627] | −2.5 |
| Klhl17 | kelch-like 17 (Drosophila) (Klhl17), [NM_198305] | −4.8 |
| Lars2 | leucyl-tRNA synthetase, mitochondrial (Lars2), nuclear gene encoding mitochondrial protein, [NM_153168] | −3.6 |
| Lrrk1 | leucine-rich repeat kinase 1 (Lrrk1), [NM_146191] | −2.7 |
| Lztr1 | leucine-zipper-like transcriptional regulator, 1 (Lztr1), [NM_025808] | −3.4 |
| Mapk8ip3 | mitogen-activated protein kinase 8 interacting protein 3 (Mapk8ip3), [NM_013931] | −2.9 |
| Mcm8 | minichromosome maintenance deficient 8 (S. cerevisiae) (Mcm8), [NM_025676] | −2.4 |
| Med25 | TCBAP0758 protein (Fragment) homolog [Homo sapiens], [AK165760] | −5.4 |
| Mr1 | laminin receptor 1 (ribosomal protein SA) (Lamr1), [NM_011029] | −2.6 |
| Napa | N-ethylmaleimide sensitive fusion protein attachment protein alpha (Napa), [NM_025898] | −3.0 |
| Ndrg1 | N-myc downstream regulated gene 1 (Ndrg1), [NM_010884] | −3.3 |
| Nsfl1c | NSFL1 (p97) cofactor (p47) (Nsfl1c), [NM_198326] | −2.2 |
| Otud5 | bZ30I22.1 (Novel protein similar to human FLJ12550) (Fragment) homolog [Brachydanio rerio], [AK169921] | −3.1 |
| Pank4 | pantothenate kinase 4 (Pank4), [NM_172990] | −3.0 |
| Pgls | 6-phosphogluconolactonase, [AK158308] | −5.6 |
| Phkg2 | phosphorylase kinase, gamma 2 (testis) (Phkg2), [NM_026888] | −3.3 |
| Pmaip1 | phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1), [NM_021451] | −6.6 |
| Pola2 | polymerase (DNA directed), alpha 2 (Pola2), [NM_008893] | −2.7 |
| Polg | polymerase (DNA directed), gamma 2, accessory subunit (Polg2), [NM_015810] | −3.2 |
| Rnf126 | ring finger protein 126 (Rnf126), [NM_144528] | −2.1 |
| Ropn1l | ropporin 1-like (Ropn1l), [NM_145852] | −6.8 |
| Rtel1 | regulator of telomere elongation helicase 1 (Rtel1), [NM_001001882] | −4.3 |
| Slc1a5 | solute carrier family 1 (neutral amino acid transporter), member 5 (Slc1a5), [NM_009201] | −2.3 |
| Slc25a28 | solute carrier family 25, member 28 (Slc25a28), [NM_145156] | −2.9 |
| Snapc4 | small nuclear RNA activating complex, polypeptide 4 (Snapc4), [NM_172339] | −2.7 |
| Solh | small optic lobes homolog (Drosophila) (Solh), [NM_015830] | −3.9 |
| Synj1 | PREDICTED: synaptojanin 1 (Synj1), [XM_358889] | −2.8 |
| Trim21 | tripartite motif protein 21 (Trim21), [NM_009277] | −11.4 |
| Trpm2 | transient receptor potential cation channel, subfamily M, member 2 (Trpm2), [NM_138301] | −4.2 |
| Trpm7 | transient receptor potential cation channel, subfamily M, member 7 (Trpm7), [NM_021450] | −3.2 |
| Ube3b | ubiquitin protein ligase E3B (Ube3b), [NM_054093] | −2.8 |
| Upp1 | uridine phosphorylase 1 (Upp1), [NM_009477] | −3.4 |
Fold change: ITD-Flt3+ KLS cells derived from CreER-Survivinfx/fx compared to control Survivinfx/fx in two experiments.