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. 2003 Dec 12;5:228–237. doi: 10.1251/bpo66

Table 1.

Sequencing result of individual cDNA/Protein that binds to p62’s UBA domain

Well # Plasmid cDNA Homology and resulting protein Putative function
A7 #19 98% Myelin basic protein Decreased in Alzheimer’s Disease (AD)
A7 #23 98% 14-3-3 protein zeta isoform Located in neurofibrillary tangles of AD
B4 #18 96% Syntaxin binding protein (munc18) 1 Interact with X11 and reduce b-amyloid
B4 #24 99% FK506 binding protein (FKBP) 14 Ligands as neurological disorders therapeutics
C5 #19 99% Homeobox protein Meis2 Brain development
E7 #9 97% Transketolase Decreased activity in dementia of AD
E7 #15 100% Heat shock cognate hsp70 Protect cell death
F3 #10 97% Reelin isoform b Suppress tau Phosphorylation
G8 #16 94% Calcium/calmodulin kinase II May phosphate tau, leading to AD
G8 #24 99% Unc51 like kinase II Plays role in axonal elongation
G10 #13 98% Nuclear receptor co-repressor 1 Link with Huntington’s disease