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. Author manuscript; available in PMC: 2011 Jan 17.
Published in final edited form as: Am J Rhinol Allergy. 2010 May;24(3):192–196. doi: 10.2500/ajra.2010.24.3460

Figure 4.

Figure 4

Expression of growth-associated protein (GAP) 43 and neural cell adhesion molecule (NCAM) is reduced with TNF-α expression, but recovers quickly when TNF-α expression is discontinued. Inducible olfactory inflammation (IOI) mice administered 0.5 mg/mL of doxycycline in their drinking water for 0–5 weeks were killed and olfactory tissue was isolated and examined by Western blot for expression of neuronal marker proteins. (A) NCAM and GAP-43 expression are reduced in a time-dependent manner after induction of TNF-α. When TNF-α expression is discontinued, GAP-43 and NCAM expression returns to near normal levels. (B) Western blots were examined by densitometry and expressed graphically. As shown, GAP-43 and NCAM expression are reduced time dependently during TNF-α expression, with a brief increase in expression at around 7 days. In the absence of TNF-α, expression levels return to near normal levels.