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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Biotechnol J. 2010 Jul;5(7):768–780. doi: 10.1002/biot.201000059

Fig. 2.

Fig. 2

Objective function array for parameter sets with Pareto rank = 0 for the original POET implementation (gray circles) and POET with local parameter refinement (black circles). Eight objectives are shown from the 24-objectives used in the model identification. The symbol Oj indicates the jth objective function. Points indicate the error associated with ensemble parameter sets. Objectives were defined using a (3,2,2,2)-level factorial design (ligand,gene1,gene2,gene3): O1 = (2,2,1,1),O2 = (2,2,1,2),O3 = (2,2,2,1),O4 = (2,2,2,2),O5 = (3,2,1,1),O6 = (3,2,1,2),O7 = (3,2,2,1) and O8 = (3,2,2,2). Design levels: Ligand (1,2,3) = (0,10,50) and gene j (1,2) = (deleted,present).