Table 2.
Examples of neuropsychiatric disease-related genes studied in ZF
| Disease | Gene | Technique used | Reference |
|---|---|---|---|
| Drug dependency (ethanol) | fan | ENU mutagenesis, cloning | Peng, Wagle et al. 2009 |
| Drug dependency (amphetamine) | calcineurin B | microarray analysis | Kily, Cowe et al. 2008 |
| Autism | SUSD4 | MO knockdown | Tu, Cohen et al. 2010 |
| neuroligin | studied expression patterns | Rissone, A., L. Sangiorgio, et al. 2010 | |
| neurexin | studied ZF homologs | Rissone, A., M. Monopoli, et al. 2007 | |
| Met/HGF | MO knockdown | Elsen, Choi et al. 2009 | |
| Fragile X Syndrome | FMR-1 | TILLING | den Broeder, van der Linde et al. 2009 |
| MO knockdown | Tucker, Richards et al. 2006 | ||
| miRNA transgenes | Lin, Chang et al. 2006 | ||
| Schizophrenia | disc-1 | MO knockdown | Drerup, Wiora et al. 2009 |
| nrg1 | MO knockdown | Wood, Bonath et al. 2009 | |
| ndel1a, ndel1b | studied expression patterns | Drerup, C. M., S. C. Ahlgren, et al. 2007 | |
| ophelia | mutagenesis | Burgess and Granato 2007 |
ZF = zebrafish, MO = morpholino, TILLING = targeted induced local lesions in genomes