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Inhibition of PI3K signalling inhibits SGK1 phosphorylation and B-13 transdifferentiation. (A) B-13 cells were treated with or without DEX (10 nM) or LY294002 (5 μM). After 14 days, cells appeared typically as shown. (B) Cells harvested and analysed for the indicated protein by western blotting. CPS, carbamoyl phosphate synthase I. Data are typical of at least three independent experiments. (C) Schematic diagram illustrating overlap between the WNT and PI3K pathways.
