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. 2011 Jan 11;124(3):459–468. doi: 10.1242/jcs.076240

Fig. 10.

Fig. 10.

Simultaneous depletion of LAPTMs and MCOLN1 increases lysosomal inclusion size. (A,B) Quantification of the number and size of the electron-dense and multiconcentric structures accumulated under the following conditions (n represents the number of cells analyzed per condition): HeLa cells treated with control non-target siRNA (siControl, n=54), HeLa cells treated with siRNAs against both LAPTM4a and LAPTM4b (siLAPTM, n=51), stable HeLa cell line infected with lentivirus-mediated shRNA against MCOLN1 (shMCOLN1, n=16), stable HeLa MCOLN1-deficient cell line transfected with siRNAs against LAPTM4a and LAPTM4b (shMCOLN1+ siLAPTM, n=14).