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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Clin Cancer Res. 2010 Jun 22;16(13):3399–3408. doi: 10.1158/1078-0432.CCR-09-3087

Figure 1.

Figure 1

Multiple low-dose CpG oligonucleotide (CpG-ODN) injections improve survival of glioma-bearing mice. Mice bearing four-day old intracranial GL261-ffLuc tumors were treated with single (x1), two (x2) or four (x4) intratumoral injections of low-dose CpG-ODN (3μg/injection), control ODN (3μg/injection), or phosphate buffered saline (PBS) every four days (arrows). (A) Intracranial tumor burden was assessed by biophotonic imaging of mice at day 7, 14 and 21-post tumor injection. (B) Kaplan-Meier analysis demonstrates improved survival for mice that received four injections of CpG-ODN but not control ODN. (C) Survival was also improved in mice receiving two injections of CpG-ODN but not control ODN. n=7 mice/group, P values determined by Student’s T test. Data is representative of two separate experiments.