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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Clin Cancer Res. 2010 Jun 22;16(13):3399–3408. doi: 10.1158/1078-0432.CCR-09-3087

Figure 5.

Figure 5

Anti-glioma effect of low-dose CpG-ODN is primarily mediated by NK cells. naïve mice were depleted of CD8 or NK cells by i.p. injection of relevant mAb or control IgG (200 μg/injection) one day prior to tumor implantation and each CpG-ODN treatment (3μg/injection, arrows). (A) Intracranial tumor burden was assessed by biophotonic imaging of mice at day 14 and 21 post tumor implantation. NK-depleted mice exhibited more rapid tumor growth. (B) Kaplan-Meier analysis demonstrates lower survival rate for mice that were depleted of NK cells (p=0.348). n=6 mice for each group. Data is representative of two separate experiments.