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. 2011 Jan 17;6(1):e14526. doi: 10.1371/journal.pone.0014526

Figure 6. Platelet depletion suppresses the increased angiogenic switch in RT2/HRG+/+ mice.

Figure 6

RT2/HRG+/+ and RT2/HRG−/− mice (n = 6/group) were rendered thrombocytopenic by treatment with an anti-GP1bα antibody during two weeks before the onset of the angiogenic switch. At 7 weeks of age angiogenic islets were counted in each animal. A second group of RT2/HRG−/− mice were treated with the anti-GP1bα antibody during two weeks after the angiogenic switch and tumor volumes analyzed at 12 weeks of age (n = 6/group). (Data on untreated animals at 7 weeks were originally published in [3].) Statistical analyses were performed with a two-tailed Mann-Whitney test, vertical bars represent standard deviation, ** p≤0.001, ns = non significant.