Table 3.
Gene expression alteration of hMSCs in scaffold (signal transduction)
| Symbol | Gene name | Ref Seq Number | Fold change |
|---|---|---|---|
| GYS1 | Glycogen synthase 1 (muscle) | NM_002103 | 45.14 |
| GADD45A | Growth arrest and DNA-damage-inducible, alpha | NM_001924 | 38.32 |
| EGFR | Epidermal growth factor receptor | NM_005228 | 25.68 |
| WISP2 | WNT1 inducible signaling pathway protein 2 | NM_003881 | 22.74 |
| NAB2 | NGFI-A binding protein 2 (EGR1 binding protein 2) | NM_005967 | 18.21 |
| ICAM1 | Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | NM_000201 | 17.70 |
| TMEPAI | Transmembrane, prostate androgen induced RNA | NM_020182 | 17.17 |
| TCF7 | Transcription factor 7 (T-cell specific, HMG-box) | NM_003202 | 16.83 |
| CSF2 | Colony stimulating factor 2 (granulocyte-macrophage) | NM_000758 | 16.43 |
| TANK | TRAF family member-associated NFKB activator | NM_004180 | 16.27 |
| CDKN2C | Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | NM_078626 | 16.15 |
| NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | NM_003998 | 15.51 |
| CDKN2D | Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | NM_001800 | 15.38 |
| RBBP8 | Retinoblastoma binding protein 8 | NM_002894 | 15.35 |
| NFKBIA | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | NM_020529 | 14.72 |
| CSN2 | Casein beta | NM_001891 | 13.64 |
| CDX1 | Caudal type homeobox transcription factor 1 | NM_001804 | 13.45 |
| JUN | Jun oncogene | NM_002228 | 12.64 |
| FOS | V-fos FBJ murine osteosarcoma viral oncogene homolog | NM_005252 | 12.53 |
| PPARG | Peroxisome proliferator-activated receptor gamma | NM_015869 | 11.71 |
| HSP90AA2 | Heat shock protein 90kDa alpha (cytosolic), class A member 2 | NM_001040141 | 11.27 |
| WISP1 | WNT1 inducible signaling pathway protein 1 | NM_003882 | 10.94 |
| FASN | Fatty acid synthase | NM_004104 | 10.42 |
| HK2 | Hexokinase 2 | NM_000189 | 9.42 |
| BIRC5 | Baculoviral IAP repeat-containing 5 (survivin) | NM_001168 | 8.45 |
| JUNB | Jun B proto-oncogene | NM_002229 | 8.11 |
| STRA6 | Stimulated by retinoic acid gene 6 homolog | NM_022369 | 7.01 |
| CTSD | Cathepsin D | NM_001909 | 6.95 |
| BCL2 | B-cell CLL/lymphoma 2 | NM_000633 | 6.15 |
| MYC | V-myc myelocytomatosis viral oncogene homolog (avian) | NM_002467 | 5.71 |
| BMP4 | Bone morphogenetic protein 4 | NM_130851 | 5.56 |
| WNT1 | Wingless-type MMTV integration site family, member 1 | NM_005430 | 5.46 |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | NM_004064 | 5.32 |
| TFRC | Transferrin receptor (p90, CD71) | NM_003234 | 5.06 |
| CXCL9 | Chemokine (C-X-C motif) ligand 9 | NM_002416 | 4.90 |
| CDKN1C | Cyclin-dependent kinase inhibitor 1C (p57, Kip2) | NM_000076 | 4.67 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | NM_005194 | 4.49 |
| A2M | Alpha-2-macroglobulin | NM_000014 | 4.25 |
| IL4R | Interleukin 4 receptor | NM_000418 | 3.78 |
| BRCA1 | Breast cancer 1, early onset | NM_007294 | 3.63 |
| BAX | BCL2-associated X protein | NM_004324 | 3.59 |
| ATF2 | Activating transcription factor 2 | NM_001880 | 3.37 |
| IRF1 | Interferon regulatory factor 1 | NM_002198 | 3.36 |
| CDK2 | Cyclin-dependent kinase 2 | NM_001798 | 3.07 |
| BMP2 | Bone morphogenetic protein 2 | NM_001200 | 3.01 |
| EGR1 | Early growth response 1 | NM_001964 | 2.99 |
| BIRC3 | Baculoviral IAP repeat-containing 3 | NM_001165 | 2.63 |
| IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells | NM_001556 | 2.56 |
| CCL2 | Chemokine (C-C motif) ligand 2 | NM_002982 | 2.39 |
| EN1 | Engrailed homeobox 1 | NM_001426 | 2.19 |
| BIRC2 | Baculoviral IAP repeat-containing 2 | NM_001166 | 1.74 |
| CDKN2A | Cyclin-dependent kinase inhibitor 2A | NM_000077 | 1.63 |
| CDKN2B | Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | NM_004936 | 1.58 |