Table 1.
The ErbB4 Q646C mutant exhibits tumor suppressor activity in the human pancreatic tumor cell lines
| Cell Lines | Viruses | Drug Resistant Colonies per mL of Virus |
Clonogenic Proliferation Efficiency (% of C127) |
Inhibition of Clonogenic Proliferation (%) |
|---|---|---|---|---|
| C127 | Vector | 2.6×105 | 100 | |
| ErbB4 WT | 2.9×105 | 100 | ||
| ErbB4 Q646C | 5.6×105 | 100 | ||
|
| ||||
| CaPan-1 | Vector | 1.3×102 | 0.043 (N=3) | |
| ErbB4 WT | 1.9×102 | 0.061 (N=4) | None (N=3) | |
| ErbB4 Q646C | 6.9×100 | 0.001 (N=4) | 99±1 (N=3) | |
|
| ||||
| HPAC | Vector | 1.6×105 | 65 (N=5) | |
| ErbB4 WT | 1.5×105 | 59 (N=5) | 7±11 (N=5) | |
| ErbB4 Q646C | 4.1×104 | 7.0 (N=5) | 88±4 (N=5) | |
|
| ||||
| PANC-1 | Vector | 1.0×104 | 4.3 (N=4) | |
| ErbB4 WT | 1.2×104 | 4.0 (N=4) | None (N=4) | |
| ErbB4 Q646C | 6.0×103 | 1.1 (N=4) | 71±14 (N=4) | |
|
| ||||
| MIA PaCa-2 | Vector | 4.7×104 | 20 (N=4) | |
| ErbB4 WT | 5.8×104 | 22 (N=4) | None (N=4) | |
| ErbB4 Q646C | 3.6×104 | 5.6 (N=4) | 71±8 (N=4) | |