Table 1.
Clinical data of patients and proportion of wt to total ATTR in cardiac tissue
| Patient no. | Sex | Age at onset of symptomatic disease (years) | Duration of symptomatic disease (years) | Duration after LT (years) | wtATTR proportion [mean (range), %] | |||
|---|---|---|---|---|---|---|---|---|
| Homogenized | Paraffin-embedded | |||||||
| Intact ATTR | Fragmented ATTR | Intact ATTR | Fragmented ATTR | |||||
| Fibril type A (fragmented ATTR present) | ||||||||
| Pre-LT | ||||||||
| 1 | M | 69 | 5.5 | – | 73 (68–77) | 78 (74–82) | 74 (65–80) | 79 (77–81) |
| 2 | M | NK | NK | – | 69 (65–75) | 77 (77–78) | NA | NA |
| 3 | F | NK | NK | – | 72 (69–74) | 76 (73–78) | 72 (68–76) | 77 (68–85) |
| 4 | M | NK | 13 | – | 73 (71–75) | 79 | 70 | 81 |
| 5 | M | 62 | 13 | – | 75 (74–76) | 85 (82–88) | 75 (69–84) | 81 (76–89) |
| 6 | M | NK | NK | – | 74 (71–79) | 79 (73–84) | 74 (71–77) | 79 (78–79) |
| Mean ± SD | 65 ± 3.5 | 10 ± 3.5 | – | 73 ± 2.1 | 79 ± 3.5 | 73 ± 2.0 | 79 ± 1.7 | |
| Post-LT | ||||||||
| 7 | M | 65 | 10 | 7 | 96 (95–97) | 97 (96–98) | NA | NA |
| Fibril type B (fragmented ATTR not present) | ||||||||
| Pre-LT | ||||||||
| 8 | F | 52 | 10 | – | 43 (40–45) | – | NA | – |
| 9 | F | 46 | 11 | – | 52 (51–54) | – | 53 (50–57) | – |
| 10 | F | NK | NK | – | 51 (49–52) | – | 59 (54–63) | – |
| 11 | NK | NK | NK | – | 57 (54–60) | – | NA | – |
| 12 | M | NK | NK | – | 57 (55–59) | – | 52 | – |
| Mean ± SD | 49 ± 4.2 | 10.5 ± 0.7 | – | 52 ± 5.7 | – | 55 ± 3.8 | – | |
NK not known, NA not available