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SPC inhibits PMN adhesion to activated endothelium under flow in vitro and PMN recruitment in the infarction area in vivo. (a) PMN adhesion to TNF-α-activated endothelial cells in vitro in the presence and absence of 10 μM SPC as quantified in a parallel-plate flow-chamber system. (b) Representative immunohistochemistry and morphometric quantification of PMN in infarcts of vehicle- and SPC-treated mice, respectively, 24 hours after ischemia/reperfusion.
